Endocrine Abstracts

Type 1 iodothyronine deiodinase (D1) is responsible for the conversion of thyroxin (T4) into tri-iodothyronine (T3). The enzyme is mainly present in thyroid, liver and kidneys.There is strong evidence that the metabolism of thyroid hormones is disturbed in some neoplasmatic tissues. However there are only few available data about D1 enzymatic activity in liver tumors.The aim of this study was to estimate the e...

Introduction: Measurement of the baseline level of 17-hydroxyprogesterone (17OHP) is a screening test for NCAH, a less severe form of congenital adrenal hyperplasia.Aim: A real-life verification of the currently adopted 17OHP threshold (≥2.0 ng/ml) at which the further diagnostic (cosyntropin stimulation test) should be performed.Material and methods: The study included 400 patients (385 females and 15 males) referred to the ...

Cosyntropin stimulation test is the gold diagnostic standard used to test for NCAH. Genetic testing is not currently considered to be the primary diagnostic tool for NCAH. Still, it may be helpful in establishing a diagnosis if other results are unequivocal or for genetic counselling purposes. The study aimed at verifying the currently accepted threshold of 17-hydroxyprogesterone (17OHP) level (3 2.0 ng/ml) at which a cosyntropin stimulation test should be performed...